Pannexin1 as mediator of inflammation and cell death

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Pannexin1 as mediator of inflammation and cell death.

Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasom...

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ژورنال

عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

سال: 2017

ISSN: 0167-4889

DOI: 10.1016/j.bbamcr.2016.10.006